Heparins Attenuate Cancer Metastasis: Are Selectins the Link?
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منابع مشابه
Heparins attenuate cancer metastasis: are selectins the link?
Heparin is often used to prevent or treat thromboembolism in cancer patients. Clinical and experimental evidence suggest that heparin also has anticancer activities. Experimental evidence consistently supports the ability of heparin to attenuate metastasis. The potential antimetastatic effects of heparin include inhibition of cell-cell interactions and heparanase and modulation of growth factor...
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Cell adhesion molecules play a significant role in cancer progression and metastasis. Cell-cell interactions of cancer cells with endothelium determine the metastatic spread. In addition, direct tumor cell interactions with platelets, leukocytes, and soluble components significantly contribute to cancer cell adhesion, extravasation, and the establishment of metastatic lesions. Clinical evidence...
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ژورنال
عنوان ژورنال: Cancer Investigation
سال: 2009
ISSN: 0735-7907,1532-4192
DOI: 10.1080/07357900802647136